Clostridium difficile colitis is reported as a side effect among people who take Azithromycin (azithromycin), especially for people who are male, 60+ old, have been taking the drug for 1 month also take Omeprazole, and have Pseudomonas infection. We included all patients (all ages and both inpatients and outpatients) with diarrhea and positive C. difficile toxin in stool, detected via nucleic acid amplification using a real-time polymerase chain reaction (PCR) assay (the GeneXpert technique). Antibiotics are the greatest risk factor for Clostridioides difficile infection (CDI). Risk for CDI varies across antibiotic types and classes. Optimal prescribing and stewardship recommendations require comparisons of risk across antibiotics. Some antibiotics put patients at higher risk of C. diff infection. Share this video across social media, websites, or digital channels to raise awareness about the link between certain antibiotics and C. diff infection. Antibiotics are the greatest risk factor for Clostridioides difficile infection (CDI). Risk for CDI varies across antibiotic types and classes. Optimal prescribing and stewardship recommendations require comparisons of risk across antibiotics. Azithromycin does carry a risk of Clostridioides difficile infection, though it appears to have a lower risk compared to other antibiotic classes such as fluoroquinolones, clindamycin, and cephalosporins. All antibiotics are thought to increase the risk of Clostridium difficile diarrhea, but current evidence suggests that particular drug classes are much worse than others in increasing this risk. Yes, administration of azithromycin increases the risk for Clostridioides difficile (C. diff) infection. The use of azithromycin, like nearly all antibacterial agents, can alter the normal flora of the colon, leading to overgrowth of C. difficile. Azithromycin, a macrolide antibiotic, does have the risk of causing a Clostridium difficile (i.e. C. Diff) infection, like any systemic antibiotic therapy, does. Antibiotics less likely to cause C.Diff include azithromycin, clarithromycin, doxycycline, erythromycin, fidaxomicin, minocycline, and metronidazole. Effective C.Diff treatment requires specific antibiotics like oral vancomycin, highlighting the importance of targeted antibiotic use and stewardship programs to reduce unnecessary prescribing.